CS244849B2 - Production method of new amides of substituted piperazin-1 yl acetic acid - Google Patents

Production method of new amides of substituted piperazin-1 yl acetic acid Download PDF

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Publication number
CS244849B2
CS244849B2 CS851217A CS121785A CS244849B2 CS 244849 B2 CS244849 B2 CS 244849B2 CS 851217 A CS851217 A CS 851217A CS 121785 A CS121785 A CS 121785A CS 244849 B2 CS244849 B2 CS 244849B2
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CS
Czechoslovakia
Prior art keywords
acid
formula
addition salts
acids
piperazide
Prior art date
Application number
CS851217A
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Czech (cs)
English (en)
Other versions
CS121785A2 (en
Inventor
Karl Schoenafinger
Rudi Beyerle
Ursula Schindler
Piero Martorana
Rolf-Eberhard Nitz
Original Assignee
Cassella Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Cassella Ag filed Critical Cassella Ag
Publication of CS121785A2 publication Critical patent/CS121785A2/cs
Publication of CS244849B2 publication Critical patent/CS244849B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS851217A 1983-04-28 1984-04-25 Production method of new amides of substituted piperazin-1 yl acetic acid CS244849B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833315424 DE3315424A1 (de) 1983-04-28 1983-04-28 Substituierte piperazin-1-yl-essigsaeure-amide, verfahren zu ihrer herstellung und ihre verwendung
CS843071A CS244811B2 (en) 1983-04-28 1984-04-25 Production method of new amides of substituted piperazin-1.yl-acetic acid

Publications (2)

Publication Number Publication Date
CS121785A2 CS121785A2 (en) 1985-09-17
CS244849B2 true CS244849B2 (en) 1986-08-14

Family

ID=6197594

Family Applications (2)

Application Number Title Priority Date Filing Date
CS843071A CS244811B2 (en) 1983-04-28 1984-04-25 Production method of new amides of substituted piperazin-1.yl-acetic acid
CS851217A CS244849B2 (en) 1983-04-28 1984-04-25 Production method of new amides of substituted piperazin-1 yl acetic acid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS843071A CS244811B2 (en) 1983-04-28 1984-04-25 Production method of new amides of substituted piperazin-1.yl-acetic acid

Country Status (19)

Country Link
US (1) US4610984A (en])
EP (1) EP0123977A1 (en])
JP (1) JPS59205363A (en])
KR (1) KR840008347A (en])
AU (1) AU2747384A (en])
CA (1) CA1202304A (en])
CS (2) CS244811B2 (en])
DD (1) DD223711A5 (en])
DE (1) DE3315424A1 (en])
DK (1) DK147784A (en])
ES (1) ES532011A0 (en])
FI (1) FI841461A7 (en])
GR (1) GR81494B (en])
HU (1) HUT34178A (en])
IL (1) IL71657A0 (en])
NO (1) NO841464L (en])
PL (2) PL253669A1 (en])
PT (1) PT78488B (en])
ZA (1) ZA843138B (en])

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8512163D0 (en) * 1985-05-14 1985-06-19 Fujisawa Pharmaceutical Co Oxothiazolidine compound
US5110929A (en) * 1986-08-07 1992-05-05 Medice Cham.-Pharm. Fabrik Putter Gmbh & Co. Kg Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles
IT1249728B (it) * 1991-11-06 1995-03-09 Sigma Tau Ind Farmaceuti Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono
DE19904710A1 (de) * 1999-02-05 2000-08-10 Aventis Pharma Gmbh Substituierte 4-Amino-2-aryl-tetrahydrochinazoline, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2007016496A2 (en) * 2005-08-02 2007-02-08 Neurogen Corporation Dipiperazinyl ketones and related analogues

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081564A1 (en) * 1970-03-05 1971-12-10 Delalande Sa N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics
BE774447A (fr) * 1970-11-11 1972-02-14 Biasedra Lab Nouveaux derives de la salicylamide et leur application en therapeutique
US4247549A (en) * 1978-12-27 1981-01-27 Ici Americas Inc. Piperazine-1-carboxylic acid esters possessing antidepressant or analgesic activity
WO1982003861A1 (en) * 1981-05-08 1982-11-11 Tominaga Michiaki Aniline derivatives,process for their preparation,and cardiotonics

Also Published As

Publication number Publication date
DD223711A5 (de) 1985-06-19
PL253669A1 (en) 1986-02-11
ES8502103A1 (es) 1984-12-16
ZA843138B (en) 1984-11-28
FI841461A7 (fi) 1984-10-29
JPS59205363A (ja) 1984-11-20
KR840008347A (ko) 1984-12-14
HUT34178A (en) 1985-02-28
PT78488A (de) 1984-05-01
DK147784D0 (da) 1984-02-29
GR81494B (en]) 1984-12-11
CS307184A2 (en) 1985-09-17
PL247414A1 (en) 1985-10-08
EP0123977A1 (de) 1984-11-07
CS244811B2 (en) 1986-08-14
DK147784A (da) 1984-10-29
PT78488B (de) 1986-05-22
IL71657A0 (en) 1984-07-31
DE3315424A1 (de) 1984-12-20
ES532011A0 (es) 1984-12-16
CA1202304A (en) 1986-03-25
US4610984A (en) 1986-09-09
AU2747384A (en) 1984-11-01
CS121785A2 (en) 1985-09-17
NO841464L (no) 1984-10-29
FI841461A0 (fi) 1984-04-12

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